The Jonas Brothers have marked two decades in the music industry with the release of “I Can’t Lose”, their third single from the forthcoming album Greetings from Your Hometown, due out on August 8, 2025. Dropped on July 15, the upbeat disco-pop track premiered live during a Mastercard-backed event benefiting Stand Up to Cancer, fittingly combining their celebratory milestone with charitable outreach.
The song’s debut featured a special performance for cancer-impacted fans, with Mastercard pledging one cent per qualifying purchase—up to $5 million—to the Stand Up to Cancer campaign through August 22. The music video, filmed during the live event, premiered simultaneously with the single during the July 15, 2025 MLB All-Star Game.
Nick Jonas describes “I Can’t Lose” as a message of hope and perseverance: verses addressing daily hardships build to a chorus that’s an anthem for resilience. Nick emphasized the song’s dual purpose: to uplift listeners and support those facing cancer.
This release follows their previous disco-pop singles “Love Me to Heaven” (March 21) and “No Time to Talk” (June 20), the latter sampling the Bee Gees’ classic “Stayin’ Alive”. With heartfelt nods to ‘70s pop, the new material blends nostalgic influence with modern energy, aligning with the brothers’ intent to both celebrate and evolve their sound as they enter this milestone year.
Their anniversary tour, Jonas20: Greetings from Your Hometown, kicks off August 10, 2025, at MetLife Stadium in East Rutherford, New Jersey, and runs through November 14, covering 52 North American shows. The performances will span their entire catalog—Jonas Brothers classics, Nick and Joe’s solo work, and DNCE songs—with supporting acts like Marshmello, All‑American Rejects, and Boys Like Girls. Though six originally slated stadium dates were downsized to smaller venues due to ticketing concerns, the brothers emphasized that all scheduled city dates remain intact.
PEOPLE’s exclusive interview highlights Nick’s pride in their enduring, multi-generational fanbase—original fans now bring their kids, while newer fans connect with the brothers’ later-era work. The group’s cultural impact is further underscored by their partnership with breast cancer charity—combining meaningful outreach with high-energy music releases.
“I Can’t Lose” not only celebrates longevity but embodies the Jonas Brothers’ ongoing mission: to inspire, entertain, and uplift. As they prepare for the album and tour, fans anticipate a harmonious look back and a confident leap forward in their musical journey.